منابع مشابه
Finding schizophrenia genes.
Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings...
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New studies have substantially advanced our understanding of the genetic architecture of schizophrenia, but we are far from identifying the underlying mutations. We may require new approaches to understand the biological implications of insights into the genetics of psychiatric disease.
متن کاملSchizophrenia: genes at last?
Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified several potential regions of linkage and two associated chromosomal abnormalities, and evidence is accumulating in favour of several positional candidate genes. Current...
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S chizophrenia is a devastating brain disease that affects ∼1% of the population worldwide and is characterized by a complex array of positive (delusions and hallucinations), negative (apathy and social withdrawal), and cognitive (deficits in attention and working memory) symptoms. Clinical features of schizophrenia frequently arise during late adolescence or early adulthood, which places this ...
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enough that they might represent two portions of the same gene. Of the 215 protein-coding regions reported by Bowman et al., GlimmerM automatically finds 214 of them. (An earlier version of GlimmerM was provided to the annotators of chromosome 3.) The only gene missed is a short hypothetical protein (PFC0360w, 114 amino acids) with no homology to any known gene. Finally, given that chromosome 3...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2005
ISSN: 0021-9738
DOI: 10.1172/jci24759